Electrochemical Aerobic Oxidation of Aminocyclopropanes to Endoperoxides


  • We warmly thank Dr. Sophie Susplugas and Prof. Philippe Grellier from the Muséum National d'Histoire Naturelle (Paris, France) for the evaluation of the in vitro antimalarial activity of our compounds.


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Electrical synthesizer: Results of cyclic voltammetric studies on a range of aminocyclopropanes in the absence or in the presence of oxygen are in full agreement with the currently accepted autocatalytic mechanism for the aerobic oxidation of these compounds. A simple and efficient procedure was developed for the electrosynthesis of the corresponding endoperoxides (see scheme), some of which exhibit moderate antimalarial activity.