We warmly thank Dr. Sophie Susplugas and Prof. Philippe Grellier from the Muséum National d'Histoire Naturelle (Paris, France) for the evaluation of the in vitro antimalarial activity of our compounds.
Electrochemical Aerobic Oxidation of Aminocyclopropanes to Endoperoxides†
Article first published online: 17 SEP 2007
Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 46, Issue 42, pages 8046–8049, October 22, 2007
How to Cite
Madelaine, C., Six, Y. and Buriez, O. (2007), Electrochemical Aerobic Oxidation of Aminocyclopropanes to Endoperoxides. Angew. Chem. Int. Ed., 46: 8046–8049. doi: 10.1002/anie.200702903
- Issue published online: 12 OCT 2007
- Article first published online: 17 SEP 2007
- Manuscript Received: 29 JUN 2007
- cyclic voltammetry;
- electrochemical oxidation;
- small ring systems;
Electrical synthesizer: Results of cyclic voltammetric studies on a range of aminocyclopropanes in the absence or in the presence of oxygen are in full agreement with the currently accepted autocatalytic mechanism for the aerobic oxidation of these compounds. A simple and efficient procedure was developed for the electrosynthesis of the corresponding endoperoxides (see scheme), some of which exhibit moderate antimalarial activity.