Cascade Reactions Using LiAlH4 and Grignard Reagents in the Presence of Water


  • We thank the Roy J. Carver Charitable Trust and the Research Corporation for generous financial support. We thank the reviewers for their suggestions that improved this article.


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Divided we stand, together we fall: Incompatible reagents, such as water and LiAlH4, Grignard, or cuprate reagents, can be site-isolated on either side of a polydimethylsiloxane (PDMS) thimble (see scheme; SDS=sodium docecyl sulfate) for cascade reactions. The hydrophobic nature of the PDMS membrane prohibits polar molecules, such as water, from diffusing across the membrane.