Cascade Reactions Using LiAlH4 and Grignard Reagents in the Presence of Water

Authors


  • We thank the Roy J. Carver Charitable Trust and the Research Corporation for generous financial support. We thank the reviewers for their suggestions that improved this article.

Abstract

original image

Divided we stand, together we fall: Incompatible reagents, such as water and LiAlH4, Grignard, or cuprate reagents, can be site-isolated on either side of a polydimethylsiloxane (PDMS) thimble (see scheme; SDS=sodium docecyl sulfate) for cascade reactions. The hydrophobic nature of the PDMS membrane prohibits polar molecules, such as water, from diffusing across the membrane.

Ancillary