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Recognition of “Mirror-Image” DNA by Small Molecules


  • Support was provided by the National Institutes of Health, the Deutsche Forschungsgemeinschaft, and the Fonds der Chemischen Industrie. C.D. is grateful to the Alexander von Humboldt foundation for a postdoctoral fellowship. D.H. is grateful to the Elite Network of Bavaria (IDK-NBT) for a doctoral fellowship.


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May the force be with you: “Mirror-image” hairpin polyamides distinguish the L enantiomer of DNA (L-DNA) in the presence of natural DNA (D-DNA). This specificity is investigated by a molecular force balance at a single-molecule level. The “DNA balance” allows the measurement of rupture forces of match/mismatch diastereomeric complexes in a single experiment.

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