We gratefully acknowledge the many co-workers who have worked on this project and the EPSRC (G.E.V. and A.B.), Alexander von Humboldt Foundation (E.B.), and Novartis (S.V.L.) for generous funding.
Synthesis of Azadirachtin: A Long but Successful Journey†
Article first published online: 30 JUL 2007
Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 46, Issue 40, pages 7629–7632, October 8, 2007
How to Cite
Veitch, Gemma E., Beckmann, E., Burke, Brenda J., Boyer, A., Maslen, Sarah L. and Ley, Steven V. (2007), Synthesis of Azadirachtin: A Long but Successful Journey. Angew. Chem. Int. Ed., 46: 7629–7632. doi: 10.1002/anie.200703027
- Issue published online: 28 SEP 2007
- Article first published online: 30 JUL 2007
- Manuscript Received: 7 JUL 2007
- Alexander von Humboldt Foundation
- Claisen rearrangement;
- radical cyclization;
- total synthesis
22 Years in the making: Azadirachtin (1) was synthesized for the first time by a highly convergent approach, utilizing a Claisen rearrangement and a radical cyclization as key steps. End-game strategies relied on intermediate 2, which could be obtained by synthetic methods as well as by degradation of 1. Bn=benzyl, TBS=tert-butyldimethylsilyl.