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Keywords:

  • azadirachtin;
  • Claisen rearrangement;
  • epoxidation;
  • radical cyclization;
  • total synthesis
Thumbnail image of graphical abstract

22 Years in the making: Azadirachtin (1) was synthesized for the first time by a highly convergent approach, utilizing a Claisen rearrangement and a radical cyclization as key steps. End-game strategies relied on intermediate 2, which could be obtained by synthetic methods as well as by degradation of 1. Bn=benzyl, TBS=tert-butyldimethylsilyl.