R.M.B. gratefully acknowledges funding from the Division of Chemical Sciences, Office of Basic Energy Sciences, US Department of Energy, and a grant by the Laboratory Directed Research and Development Program. Pacific Northwest National Laboratory is operated by Battelle for the US Department of Energy.
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An Iron Catalyst for Ketone Hydrogenations under Mild Conditions†
Article first published online: 11 SEP 2007
DOI: 10.1002/anie.200703053
Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Bullock, R. (2007), An Iron Catalyst for Ketone Hydrogenations under Mild Conditions. Angewandte Chemie International Edition, 46: 7360–7363. doi: 10.1002/anie.200703053
- †
Publication History
- Issue published online: 20 SEP 2007
- Article first published online: 11 SEP 2007
Funded by
- Division of Chemical Sciences, Office of Basic Energy Sciences, US Department of Energy
- Laboratory Directed Research and Development Program
- Abstract
- Article
- References
- Cited By
Keywords:
- homogeneous catalysis;
- hydrides;
- hydrogenation;
- iron;
- proton transfer
Graphical Abstract
Doing it on the cheap: An iron-based homogeneous catalyst for ketone hydrogenation was reported, thus avoiding the use of a precious metal. Excellent yields and chemoselectivity for hydrogenation are found under mild conditions (25 °C, 3 atm H2). An ionic hydrogenation mechanism allows the delivery of a proton from the OH group and a hydride from the metal center (see picture).