The Università del Salento (Italy) is acknowledged for financial support.
Experimental Evidence That a DNA Polymerase Can Incorporate N7-Platinated Guanines To Give Platinated DNA†
Article first published online: 3 DEC 2007
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 47, Issue 3, pages 507–510, January 4, 2008
How to Cite
Benedetti, M., Ducani, C., Migoni, D., Antonucci, D., Vecchio, Vita M., Ciccarese, A., Romano, A., Verri, T., Ciccarella, G. and Fanizzi, Francesco P. (2008), Experimental Evidence That a DNA Polymerase Can Incorporate N7-Platinated Guanines To Give Platinated DNA. Angew. Chem. Int. Ed., 47: 507–510. doi: 10.1002/anie.200703160
- Issue published online: 21 DEC 2007
- Article first published online: 3 DEC 2007
- Manuscript Revised: 18 SEP 2007
- Manuscript Received: 14 JUL 2007
- Università del Salento (Italy)
- polymerase chain reaction
Metal bearing nucleobase: A model DNA polymerase and N7-metalated purine triphosphate nucleotide are used to show that metalated purines can be inserted into DNA during an enzymatic in vitro synthetic process (see scheme; dNTP=deoxynucleotide triphosphate). The possibility of site-specific metalation of DNA mediated by DNA polymerase is demonstrated.