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Keywords:

  • DNA;
  • metalation;
  • oligonucleotides;
  • platinum;
  • polymerase chain reaction
Thumbnail image of graphical abstract

Metal bearing nucleobase: A model DNA polymerase and N7-metalated purine triphosphate nucleotide are used to show that metalated purines can be inserted into DNA during an enzymatic in vitro synthetic process (see scheme; dNTP=deoxynucleotide triphosphate). The possibility of site-specific metalation of DNA mediated by DNA polymerase is demonstrated.