We wish to express thanks to Dr. Augustin Madalan for help with X-ray diffraction radiocrystallography.
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Communication
DOSY NMR Experiments as a Tool for the Analysis of Constitutional and Motional Dynamic Processes: Implementation for the Driven Evolution of Dynamic Combinatorial Libraries of Helical Strands†
Article first published online: 14 FEB 2008
DOI: 10.1002/anie.200703168
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Giuseppone, N., Schmitt, J.-L., Allouche, L. and Lehn, J.-M. (2008), DOSY NMR Experiments as a Tool for the Analysis of Constitutional and Motional Dynamic Processes: Implementation for the Driven Evolution of Dynamic Combinatorial Libraries of Helical Strands. Angew. Chem. Int. Ed., 47: 2235–2239. doi: 10.1002/anie.200703168
- †
Publication History
- Issue published online: 3 MAR 2008
- Article first published online: 14 FEB 2008
- Manuscript Revised: 4 DEC 2007
- Manuscript Received: 16 JUL 2007
Keywords:
- diffusion NMR spectroscopy;
- dynamic combinatorial chemistry;
- molecular evolution;
- molecular helices;
- self-assembly
Diffusion ordered spectroscopy (DOSY) NMR experiments have been used to characterize a dynamic combinatorial library of helical strands and grid-type metallosupramolecular architectures. The technique allows the deconvolution of very similar chemical structures differing only by their hydrodynamic radius. Moreover, the occurrence of springlike, extension–contraction conformational motions in helical strands can be revealed as a function of the temperature.