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DOSY NMR Experiments as a Tool for the Analysis of Constitutional and Motional Dynamic Processes: Implementation for the Driven Evolution of Dynamic Combinatorial Libraries of Helical Strands

Authors

  • Nicolas Giuseppone Prof. Dr.,

    1. Institut de Science et d'Ingénierie Supramoléculaires, Université Louis Pasteur, 8 Allée Gaspard-Monge, BP 70028, 67083 Strasbourg, France, Fax: (+33) 3-9024-5140
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  • Jean-Louis Schmitt Dr.,

    1. Institut de Science et d'Ingénierie Supramoléculaires, Université Louis Pasteur, 8 Allée Gaspard-Monge, BP 70028, 67083 Strasbourg, France, Fax: (+33) 3-9024-5140
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  • Lionel Allouche Dr.,

    1. Institut de Chimie, Service de RMN, Université Louis Pasteur, 1 Rue Blaise Pascal, 67000 Strasbourg, France
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  • Jean-Marie Lehn Prof. Dr.

    1. Institut de Science et d'Ingénierie Supramoléculaires, Université Louis Pasteur, 8 Allée Gaspard-Monge, BP 70028, 67083 Strasbourg, France, Fax: (+33) 3-9024-5140
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  • We wish to express thanks to Dr. Augustin Madalan for help with X-ray diffraction radiocrystallography.

Abstract

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Diffusion ordered spectroscopy (DOSY) NMR experiments have been used to characterize a dynamic combinatorial library of helical strands and grid-type metallosupramolecular architectures. The technique allows the deconvolution of very similar chemical structures differing only by their hydrodynamic radius. Moreover, the occurrence of springlike, extension–contraction conformational motions in helical strands can be revealed as a function of the temperature.

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