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Keywords:

  • chromatin;
  • fluorous tags;
  • high-throughput screening;
  • microarrays
Thumbnail image of graphical abstract

Noncovalent immobilization is an attractive method for identifying inhibitors of histone deacetylases (HDACs). Fluorous-based small-molecule microarrays were validated as an effective method. Three enzymes and three assays (microarray, biochemical activity, and surface plasmon resonance) were used to identify inhibitors of HDACs and to compare them.