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Keywords:

  • arylation;
  • copper;
  • cross-coupling;
  • enantioselectivity;
  • homogeneous catalysis
Thumbnail image of graphical abstract

Copper makes the difference: Important challenges have been overcome in copper-catalyzed Ullmann reactions since its renaissance in the early 2000s. Significant advances in this field have recently been made in regards to carrying out enantioselective and chemoselective arylation of nucleophiles (Nu) by using a copper catalyst (see scheme).