We are grateful for financial support from the Fonds der Chemischen Industrie. A.C. thanks the Basque Government for support through the “Programa de Perfeccionamiento de Doctores en el extranjero del Departamento de Educación, Universidades e Investigación”.
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Communication
Iron-Catalyzed N-Arylation of Nitrogen Nucleophiles†
Article first published online: 17 OCT 2007
DOI: 10.1002/anie.200703299
Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Issue
Angewandte Chemie International Edition
Volume 46, Issue 46, pages 8862–8865, November 26, 2007
Additional Information
How to Cite
Correa, A. and Bolm, C. (2007), Iron-Catalyzed N-Arylation of Nitrogen Nucleophiles. Angewandte Chemie International Edition, 46: 8862–8865. doi: 10.1002/anie.200703299
- †
Publication History
- Issue published online: 16 NOV 2007
- Article first published online: 17 OCT 2007
- Manuscript Received: 23 JUL 2007
Funded by
- Fonds der Chemischen Industrie
Keywords:
- arylation;
- cross-coupling;
- diamine ligands;
- iron catalysis;
- nitrogen heterocycles
Graphical Abstract
Easy does it! A simple procedure for the N-arylation of nitrogen-containing heterocycles and primary amides relies on a catalyst formed in situ from inexpensive and environmentally benign FeCl3 and a diamine ligand. The cross-coupling reaction with aryl halides provides N-arylated compounds in high yields (see scheme; R=H, Cl, Me, OMe, CO2Et, F, CF3).