This work is supported by the Department of Energy (DE-FG02-04ER46141, U.H.F.B and V.R.) We thank Dr. A. Bommarius (Georgia Institute of Technology) and Dr. J. Hardy (University of Massachusetts Amherst) for donation of the bacterial stocks.
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Communication
Rapid and Efficient Identification of Bacteria Using Gold-Nanoparticle–Poly(para-phenyleneethynylene) Constructs†
Article first published online: 28 JAN 2008
DOI: 10.1002/anie.200703369
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Phillips, R., Miranda, O., You, C.-C., Rotello, V. and Bunz, U. (2008), Rapid and Efficient Identification of Bacteria Using Gold-Nanoparticle–Poly(para-phenyleneethynylene) Constructs. Angewandte Chemie International Edition, 47: 2590–2594. doi: 10.1002/anie.200703369
- †
Publication History
- Issue published online: 18 MAR 2008
- Article first published online: 28 JAN 2008
- Manuscript Revised: 10 OCT 2007
- Manuscript Received: 26 JUL 2007
Funded by
- Department of Energy. Grant Number: DE-FG02-04ER46141
Keywords:
- bacteria;
- bioanalysis;
- biosensors;
- conjugated polymers;
- gold nanoparticles
Graphical Abstract
Microbiological intelligence: Simple constructs of hydrophobically functionalized gold nanoarticles and a conjugated polymer (poly(para-phenyleneethynylene, PPE) are able to identify three different strains of E. coli in minutes. The negatively charged bacteria replace the negatively charged conjugated polymers from the positively charged gold nanoparticles (see scheme), differentially restoring the polymer fluorescence.