Rapid and Efficient Identification of Bacteria Using Gold-Nanoparticle–Poly(para-phenyleneethynylene) Constructs


  • This work is supported by the Department of Energy (DE-FG02-04ER46141, U.H.F.B and V.R.) We thank Dr. A. Bommarius (Georgia Institute of Technology) and Dr. J. Hardy (University of Massachusetts Amherst) for donation of the bacterial stocks.


original image

Microbiological intelligence: Simple constructs of hydrophobically functionalized gold nanoarticles and a conjugated polymer (poly(para-phenyleneethynylene, PPE) are able to identify three different strains of E. coli in minutes. The negatively charged bacteria replace the negatively charged conjugated polymers from the positively charged gold nanoparticles (see scheme), differentially restoring the polymer fluorescence.