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Keywords:

  • amino acids;
  • deoxyribozymes;
  • DNA;
  • in vitro selection;
  • nucleopeptides
Thumbnail image of graphical abstract

Joining amino acids and nucleotides: A deoxyribozyme catalyzes the nucleophilic attack of a tyrosine (Tyr) side chain on a 5′-triphosphate RNA, efficiently forming a Tyr–RNA nucleopeptide linkage (see picture). Thus, the scope of known DNA catalysis is further expanded beyond reactions of oligonucleotide functional groups.