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DNA-Catalyzed Formation of Nucleopeptide Linkages


  • This research was supported by the National Institutes of Health (GM-65966 to S.K.S. and NRSA postdoctoral fellowship to D.A.B.) and the Austrian Science Fund (Erwin Schrödinger fellowship to C.H.). S.K.S. is a Fellow of the David and Lucile Packard Foundation. We thank Amit Sachdeva for assistance and discussions.


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Joining amino acids and nucleotides: A deoxyribozyme catalyzes the nucleophilic attack of a tyrosine (Tyr) side chain on a 5′-triphosphate RNA, efficiently forming a Tyr–RNA nucleopeptide linkage (see picture). Thus, the scope of known DNA catalysis is further expanded beyond reactions of oligonucleotide functional groups.