Increasing the Complexity of Periodic Protein Nanostructures by the Rolling-Circle-Amplified Synthesis of Aptamers

Authors

  • Zoya Cheglakov,

    1. Institute of Chemistry and Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel, Fax: (+972) 2-6527715
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  • Yossi Weizmann,

    1. Institute of Chemistry and Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel, Fax: (+972) 2-6527715
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  • Adam B. Braunschweig Dr.,

    1. Institute of Chemistry and Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel, Fax: (+972) 2-6527715
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  • Ofer I. Wilner,

    1. Institute of Chemistry and Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel, Fax: (+972) 2-6527715
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  • Itamar Willner Prof.

    1. Institute of Chemistry and Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel, Fax: (+972) 2-6527715
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  • Y.W. is grateful to The Johanna Friedlander Memorial Fund for a fellowship.

Abstract

original image

The biomachinery of rolling-circle amplification relying on protein–aptamer interactions on DNA scaffolds was used to create one-dimensional DNA–protein/DNA–protein–nanoparticle hierarchical assemblies. These conjugates can serve as further templates for the immobilization of gold nanoparticles.

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