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A Sydnone Cycloaddition Route to Pyrazole Boronic Esters†

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  • †

    The authors are grateful to the EPSRC and Syngenta for financial support.

Abstract

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From dipole to diazole! A direct and regioselective route to functionalized pyrazole boronic esters is developed that employs the cycloaddition of alkynylboronates with sydnones. Functionalization of these products by Suzuki coupling and N-deprotection processes highlight the potential synthetic utility of these species.

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DOI

10.1002/anie.200703767

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Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

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Keywords

  • boronic esters;
  • cycloaddition;
  • heterocycles;
  • regioselectivity

Publication History

  • Issue online:
  • Version of record online:
  • Manuscript Received:

Funded by

  • EPSRC
  • Syngenta

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