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Keywords:

  • allylic compounds;
  • iron;
  • nucleophilic substitution;
  • regioselectivity;
  • stereoselectivity
Thumbnail image of graphical abstract

Iron at the crossroads: A remarkable mechanistic dichotomy in iron-catalyzed allylic substition increases not only the scope of regioselective allylic alkylation but could also herald the development of asymmetric allylic substitution (see Scheme, MTBE=methyl tert-butyl ether). Depending on the ligand used, either a σ- or a π-allyl mechanism is observed.