The Total Synthesis of Chlorotonil A


  • We thank R. Jansen, H. Steinmetz, and K. Gerth (HZI) for providing authentic chlorotonil A.


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Stacking the deck: The natural product chloronitril A contains an unprecedented motif in which a CCl2 unit in a 14-membered macrolide framework is flanked by two carbonyl groups. In the first total synthesis of chlorotonil A a highly selective intramolecular Diels–Alder reaction was employed to generate the decalin system.