We thank R. Jansen, H. Steinmetz, and K. Gerth (HZI) for providing authentic chlorotonil A.
The Total Synthesis of Chlorotonil A†
Article first published online: 28 NOV 2007
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 47, Issue 3, pages 597–599, January 4, 2008
How to Cite
Rahn, N. and Kalesse, M. (2008), The Total Synthesis of Chlorotonil A. Angew. Chem. Int. Ed., 47: 597–599. doi: 10.1002/anie.200703930
- Issue published online: 21 DEC 2007
- Article first published online: 28 NOV 2007
- Manuscript Received: 27 AUG 2007
- total synthesis
Stacking the deck: The natural product chloronitril A contains an unprecedented motif in which a CCl2 unit in a 14-membered macrolide framework is flanked by two carbonyl groups. In the first total synthesis of chlorotonil A a highly selective intramolecular Diels–Alder reaction was employed to generate the decalin system.