This work was funded by grants to M.F. from the Sonderforschungsbereich 624 (From the Design of Chemical Templates Towards Reaction Control). We gratefully acknowledge help from H. Rasched in generating the computer model of the minicircles.
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Communication
DNA Minicircles with Gaps for Versatile Functionalization†
Article first published online: 3 DEC 2007
DOI: 10.1002/anie.200704004
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Rasched, G., Ackermann, D., Schmidt, T., Broekmann, P., Heckel, A. and Famulok, M. (2008), DNA Minicircles with Gaps for Versatile Functionalization. Angewandte Chemie International Edition, 47: 967–970. doi: 10.1002/anie.200704004
- †
Publication History
- Issue published online: 11 JAN 2008
- Article first published online: 3 DEC 2007
- Manuscript Received: 30 AUG 2007
Keywords:
- DNA;
- DNA structures;
- functionalized DNA;
- nanostructures;
- scanning probe microscopy
Graphical Abstract
Doing the rounds: A highly straightforward approach has been developed that provides access to DNA minicircles containing a 21-mer single-stranded gap region of defined sequence (see picture). The single-stranded domain within a small circular DNA nanoobject provides the exciting opportunity to further functionalize a minicircle at defined positions in almost unlimited fashion, simply by hybridization with a synthetic 21-mer oligonucleotide.