Structural Aspects of Nucleation Inhibitors for Diastereomeric Resolutions and the Relationship to Dutch Resolution


  • We are grateful to the Samenwerkingsverband Noord- Nederland (Cooperation Northern Netherlands) and the European Fund for Regional Development (EFRO) for partial support of this work.


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You say you want a resolution: Nucleation inhibitors for the resolution of diastereomers by selective crystallization have been designed and tested. The resolution of racemic 3-methoxyphenylethylamine was optimized with (S)-mandelic acid as the resolving agent (see scheme). Multifunctional inhibitors are particularly effective.