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Keywords:

  • chiral resolution;
  • crystal growth;
  • Dutch resolution;
  • nucleation inhibitors;
  • phase diagrams
Thumbnail image of graphical abstract

You say you want a resolution: Nucleation inhibitors for the resolution of diastereomers by selective crystallization have been designed and tested. The resolution of racemic 3-methoxyphenylethylamine was optimized with (S)-mandelic acid as the resolving agent (see scheme). Multifunctional inhibitors are particularly effective.