Rhodanine-Based Tau Aggregation Inhibitors in Cell Models of Tauopathy

Authors

  • Bruno Bulic Dr.,

    1. Max-Planck-Institute for Molecular Physiology, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany
    2. Center for Applied Chemical Genomics, Otto-Hahn-Strasse 15, 44227 Dortmund, Germany
    3. Universität Dortmund, Fachbereich 3, Otto-Hahn-Strasse 6, 44227 Dortmund, Germany, Fax: (+49) 231-1332499
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    • These authors contributed equally to this work.

  • Marcus Pickhardt Dr.,

    1. Max-Planck-Unit for Structural Molecular Biology c/o DESY, Notkestrasse 85, 22607 Hamburg, Germany, Fax: (+49) 408-971-6810
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    • These authors contributed equally to this work.

  • Inna Khlistunova Dr.,

    1. Max-Planck-Unit for Structural Molecular Biology c/o DESY, Notkestrasse 85, 22607 Hamburg, Germany, Fax: (+49) 408-971-6810
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  • Jacek Biernat Dr.,

    1. Max-Planck-Unit for Structural Molecular Biology c/o DESY, Notkestrasse 85, 22607 Hamburg, Germany, Fax: (+49) 408-971-6810
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  • Eva-Maria Mandelkow Dr.,

    1. Max-Planck-Unit for Structural Molecular Biology c/o DESY, Notkestrasse 85, 22607 Hamburg, Germany, Fax: (+49) 408-971-6810
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  • Eckhard Mandelkow Prof.,

    1. Max-Planck-Unit for Structural Molecular Biology c/o DESY, Notkestrasse 85, 22607 Hamburg, Germany, Fax: (+49) 408-971-6810
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  • Herbert Waldmann Prof.

    1. Max-Planck-Institute for Molecular Physiology, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany
    2. Center for Applied Chemical Genomics, Otto-Hahn-Strasse 15, 44227 Dortmund, Germany
    3. Universität Dortmund, Fachbereich 3, Otto-Hahn-Strasse 6, 44227 Dortmund, Germany, Fax: (+49) 231-1332499
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  • This work was supported in part by grants from the Deutsche Forschungsgemeinschaft (DFG), the Institute for the Study of Aging (ISOA), the European Union (“Europäischer Fond für regionale Entwicklung”), and the state of North Rhine-Westphalia. We thank Sabrina Hübschmann and Ilka Lindner for excellent technical assistance.

Abstract

original image

Breaking up the crowd: The pathological aggregation of tau protein correlates closely with the progression of Alzheimer's disease. Rhodanine-based inhibitors of tau aggregation (e.g. 1) have been identified, and it has been shown that tau aggregation in a cell model is reversible and can be inhibited by small molecules at nanomolar concentrations (see SEM images).

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