Get access

Immortalizing a Transient Electrophile for DNA Cross-Linking

Authors


  • This work was supported by the National Science Foundation.

Abstract

original image

Who wants to live forever? Compounds that act as strong nucleophiles and good leaving groups repeatedly capture and release a transient quinone methide to extend its effective lifetime under aqueous conditions and promote DNA cross-linking (see scheme). This finding may expand the biological and therapeutic activity of quinone methides.

Ancillary