This research was supported by University of Wisconsin-Madison Nanoscale Science and Engineering Center (NSF grant DMR-0425880). V.M.Y. was supported by the Welch Foundation research grant C-1557. Authors kindly thank PepTech for a generous supply of several β-amino acids at a discounted price and Arun Yethiraj for helpful conversations during the preparation of this manuscript.
Nanofibers and Lyotropic Liquid Crystals from a Class of Self-Assembling β-Peptides†
Article first published online: 8 JAN 2008
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 47, Issue 7, pages 1241–1244, February 1, 2008
How to Cite
Pomerantz, William C., Yuwono, Virany M., Pizzey, Claire L., Hartgerink, Jeffery D., Abbott, Nicholas L. and Gellman, Samuel H. (2008), Nanofibers and Lyotropic Liquid Crystals from a Class of Self-Assembling β-Peptides. Angew. Chem. Int. Ed., 47: 1241–1244. doi: 10.1002/anie.200704372
- Issue published online: 25 JAN 2008
- Article first published online: 8 JAN 2008
- Manuscript Received: 21 SEP 2007
- University of Wisconsin-Madison Nanoscale Science and Engineering Center
- NSF. Grant Number: DMR-0425880
- liquid crystals;
- lyotropic phases;
More than a pretty phase: A class of helical β-peptides has been discovered that form lyotropic liquid-crystalline (LC) phases in water. The β-peptide sequence strongly affects the mode of assembly and ultimately whether a LC phase is formed. For a non-globally amphiphilic β-peptide that can form a LC phase, cryo-TEM revealed thin fibers several micrometers in length, consistent with Onsager theory.