Communication

Efficient Cobalt-Catalyzed Formation of Unsymmetrical Biaryl Compounds and Its Application in the Synthesis of a Sartan Intermediate

  1. Muriel Amatore2,
  2. Corinne Gosmini Dr.1

Article first published online: 7 FEB 2008

DOI: 10.1002/anie.200704402

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 47, Issue 11, pages 2089–2092, February 28, 2008

Additional Information

How to Cite

Amatore, M. and Gosmini, C. (2008), Efficient Cobalt-Catalyzed Formation of Unsymmetrical Biaryl Compounds and Its Application in the Synthesis of a Sartan Intermediate. Angew. Chem. Int. Ed., 47: 2089–2092. doi: 10.1002/anie.200704402

Author Information

  1. 1

    Laboratoire “Hétéroéléments et Coordination”, Ecole Polytechnique, CNRS, 91128 Palaiseau Cedex, France, Fax: (+33) 1-6933-4440

  2. 2

    ESO, Institut de Chimie et des Matériaux Paris Est, Université Paris, 12 Val de Marne, CNRS, 2, rue Henri Dunant, 94320 Thiais, France

Publication History

  1. Issue published online: 22 FEB 2008
  2. Article first published online: 7 FEB 2008
  3. Manuscript Revised: 29 OCT 2007
  4. Manuscript Received: 24 SEP 2007

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Keywords:

  • biaryls;
  • C[BOND]C coupling;
  • cobalt;
  • homogeneous catalysis;
  • P ligands
Thumbnail image of graphical abstract

No prior preparation of the organometallic reagent is required in a cobalt-catalyzed coupling of two different aryl halides under mild conditions (see scheme). A broad spectrum of valuable biaryl compounds can be prepared in this way. Not only may a variety of reactive substituents be present, but heteroaryl halides and aryl triflates are also suitable substrates. DMF = N,N-dimethylformamide, FG = functional group.

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