This work was supported by the Agence Nationale pour la Recherche (LnOnL, ANR-NT05-3_42676). We thank P. L. Baldeck, L. Emsley, C. Andraud, and G. Pintacuda for fruitful discussions.
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Communication
Protein Crystallography through Supramolecular Interactions between a Lanthanide Complex and Arginine†
Article first published online: 18 MAR 2008
DOI: 10.1002/anie.200704683
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Pompidor, G., D'Aléo, A., Vicat, J., Toupet, L., Giraud, N., Kahn, R. and Maury, O. (2008), Protein Crystallography through Supramolecular Interactions between a Lanthanide Complex and Arginine. Angewandte Chemie International Edition, 47: 3388–3391. doi: 10.1002/anie.200704683
- †
Publication History
- Issue published online: 14 APR 2008
- Article first published online: 18 MAR 2008
- Manuscript Received: 10 OCT 2007
Funded by
- Agence Nationale pour la Recherche. Grant Numbers: LnOnL, ANR-NT05-3_42676
Keywords:
- lanthanides;
- NMR spectroscopy;
- protein structures;
- supramolecular chemistry
Graphical Abstract
Crystal clear: Strong supramolecular interactions between tris(dipicolinate)lanthanide complexes and arginine-like moieties have been evidenced by NMR chemical shift titration and X-ray diffraction analyses. Since the lanthanide atom is a strong anomalous scatterer, and the complex itself is luminescent, this interaction could be used as a powerful tool in the preparation of crystals of protein derivatives with high phasing power.