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Pure C[BOND]H Hydrogen Bonding to Chloride Ions: A Preorganized and Rigid Macrocyclic Receptor

Authors


  • We acknowledge support from NIH 1S10RR016657-01 for the Indiana University Mass Spectrometry Facility.

Abstract

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Strength in numbers: When traditionally weak C[BOND]H hydrogen bonds are preorganized in a shape-persistent macrocycle, a strong affinity for chloride ions emerges. This discovery arises from the dual use of click chemistry for efficient macrocyclization and the favorable steric properties of the resulting 1,2,3-triazoles.

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