Get access

Pure C[BOND]H Hydrogen Bonding to Chloride Ions: A Preorganized and Rigid Macrocyclic Receptor


  • We acknowledge support from NIH 1S10RR016657-01 for the Indiana University Mass Spectrometry Facility.


original image

Strength in numbers: When traditionally weak C[BOND]H hydrogen bonds are preorganized in a shape-persistent macrocycle, a strong affinity for chloride ions emerges. This discovery arises from the dual use of click chemistry for efficient macrocyclization and the favorable steric properties of the resulting 1,2,3-triazoles.