Optical Detection of Glucose and Acetylcholine Esterase Inhibitors by H2O2-Sensitive CdSe/ZnS Quantum Dots


  • This research is supported by the James Franck Program, the VSN EC Project, and the Israel Science Foundation.


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The coupling of oxidases with fluorophore-labeled CdSe/ZnS quantum dots enables the ratiometric fluorescence analysis of enzyme activities and their substrates by the interaction between the biocatalytically generated H2O2 and the quantum dots. The method has been applied to the analyis of glucose and the inhibition of acetylcholine esterase.