This research was financially supported by the Dutch Ministry of Economic Affairs. M.A.F.-I. thanks the Spanish Ministry of Education and Science for a postdoctoral fellowship.
Catalytic Enantioselective Reformatsky Reaction with Aldehydes†
Article first published online: 4 JAN 2008
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 47, Issue 7, pages 1317–1319, February 1, 2008
How to Cite
Fernández-Ibáñez, M. Ángeles., Maciá, B., Minnaard, Adriaan J. and Feringa, Ben L. (2008), Catalytic Enantioselective Reformatsky Reaction with Aldehydes. Angew. Chem. Int. Ed., 47: 1317–1319. doi: 10.1002/anie.200704841
- Issue published online: 25 JAN 2008
- Article first published online: 4 JAN 2008
- Manuscript Received: 18 OCT 2007
- Dutch Ministry of Economic Affairs
- Ministry of Education and Science
- O ligands;
- radical reactions;
120 years after the discovery of the Reformatsky reaction, the first effective catalytic enantioselective Reformatsky reaction with aldehydes using a binol derivative as a chiral catalyst is presented (see scheme; TMS=trimethylsilyl). The reaction is performed with ethyl iodoacetate and Me2Zn. The presence of air is found to be crucial to reach high conversions and selectivities.