Iron-Catalyzed Desulfinylative C[BOND]C Cross-Coupling Reactions of Sulfonyl Chlorides with Grignard Reagents

Authors

  • Chandra M. Rao Volla,

    1. Laboratoire de Glycochimie et Synthèse Asymétrique (LGSA), Swiss Federal Institute of Technology (EPFL), Batochime, 1015 Lausanne, Switzerland, Fax: (+41) 21-693-9375
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  • Pierre Vogel Prof. Dr.

    1. Laboratoire de Glycochimie et Synthèse Asymétrique (LGSA), Swiss Federal Institute of Technology (EPFL), Batochime, 1015 Lausanne, Switzerland, Fax: (+41) 21-693-9375
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  • We are grateful to the Swiss National Science Foundation (Bern) and the Roche Research Foundation (Basel). We also thank F. Sepulveda, M. Rey, and A. Razaname for their technical help, as well as A. Yella and Dr. S. R. Dubbaka for helpful discussions.

Abstract

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A friendly couple: Conditions have been uncovered that allow the desulfinylative C[BOND]C cross-coupling reaction of inexpensive sulfonyl chlorides and Grignard reagents (see scheme, acac=acetylacetonate, NMP=N-methylpyrrolidone). The reactions rely on environmentally friendly iron catalysts and do not require expensive and/or toxic ligands.

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