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Keywords:

  • alkaloids;
  • dimerization;
  • enantioselectivity;
  • indole;
  • total synthesis
Thumbnail image of graphical abstract

On a fast track: The secondary metabolites (+)-WIN 64821 and (−)-ditryptophenaline have been synthesized in six and seven steps, respectively, from amino acid derivatives in a concise and enantioselective manner. The gram-scale synthesis of key intermediates and the simultaneous introduction of vicinal quaternary stereocenters are described. The synthesis and structural confirmation of (−)-1′-(2-phenylethylene)ditryptophenaline is also reported.