Synthesis of Rhazinicine by a Metal-Catalyzed C[BOND]H Bond Functionalization Strategy


  • We gratefully acknowledge GSK and EPSRC for studentships (E.M.B.), the Royal Society for a University Research Fellowship (M.J.G.), Philip & Patricia Brown for a Next Generation Fellowship (M.J.G.), and the EPSRC Mass Spectrometry service (University of Swansea). We are also grateful to Prof. Steven Ley for valuable support.


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Iterative and regioselective metal-catalyzed C[BOND]H bond functionalization has been utilized to develop a strategy for the first total synthesis of the pyrrole alkaloid rhazinicine (see scheme).