We gratefully acknowledge GSK and EPSRC for studentships (E.M.B.), the Royal Society for a University Research Fellowship (M.J.G.), Philip & Patricia Brown for a Next Generation Fellowship (M.J.G.), and the EPSRC Mass Spectrometry service (University of Swansea). We are also grateful to Prof. Steven Ley for valuable support.
Iterative and regioselective metal-catalyzed CH bond functionalization has been utilized to develop a strategy for the first total synthesis of the pyrrole alkaloid rhazinicine (see scheme).