Ru-Catalyzed Tandem Cross-Metathesis/Intramolecular-Hydroarylation Sequence


  • We are grateful to the National Science Foundation of China (20472021 and 20672040) and the Program for New Century Excellent Talents in University (NCET-05-0672) for support of this research. We thank Prof. Vy Dong for fruitful discussions and Materia, Inc., Pasadena, CA for the generous gift of ruthenium catalysts.


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Sometimes it only takes one to tango: A novel ruthenium-catalyzed tandem cross-metathesis/intramolecular-hydroarylation reaction of alkenyl indoles has been developed which relies on a single catalyst for the tandem sequence and provides an efficient synthesis of fused polycyclic indole compounds with good to excellent overall yields (see scheme; Ts=4-toluenesulfonyl, DCE=1,2-dichloroethane, Mes=2,4,6-Me3C6H2).