Proteins in Mesoporous Silicates

Authors

  • Sarah Hudson Dr.,

    1. Department of Chemical and Environmental Sciences, Materials and Surface Science Institute, University of Limerick, Plassey, Co. Limerick IE (Ireland), Fax: (+353) 61-213-529
    Search for more papers by this author
  • Jakki Cooney Dr.,

    1. Department of Life Sciences, Materials and Surface Science Institute, University of Limerick, Plassey, Co. Limerick IE (Ireland), Fax: (+353) 61-213-529
    Search for more papers by this author
  • Edmond Magner Prof. Dr.

    1. Department of Chemical and Environmental Sciences, Materials and Surface Science Institute, University of Limerick, Plassey, Co. Limerick IE (Ireland), Fax: (+353) 61-213-529
    Search for more papers by this author

Abstract

Mesoporous silicates (MPS) have an ordered pore structure with dimensions comparable to many biological molecules. They have been extensively explored as supports for proteins and enzymes in biocatalytic applications. Since their initial discovery, novel syntheses methods have led to precise control over pore size and structure, particle size, chemical composition, and stability, thus allowing the adsorption of a wide variety of biological macromolecules, such as heme proteins, lipases, antibody fragments, and proteases, into their structures. This Review discusses the application of ordered, large-pore, functionalized mesoporous silicates to immobilize proteins for biocatalysis.

Ancillary