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Review
Proteins in Mesoporous Silicates
Article first published online: 2 OCT 2008
DOI: 10.1002/anie.200705238
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Hudson, S., Cooney, J. and Magner, E. (2008), Proteins in Mesoporous Silicates. Angewandte Chemie International Edition, 47: 8582–8594. doi: 10.1002/anie.200705238
Publication History
- Issue published online: 21 OCT 2008
- Article first published online: 2 OCT 2008
- Manuscript Received: 14 NOV 2007
Funded by
- Enterprise Ireland. Grant Number: SC/2003/0159
- Programme for Research in Third Level Institutions
Keywords:
- biocatalysis;
- functionalization;
- mesoporous materials;
- proteins;
- silicates
Graphical Abstract
Inner beauty: Since the discovery of mesoporous silicates, novel syntheses have led to precise control over their pore size and structure, particle size, chemical composition, and stability, allowing the adsorption of a wide variety of biological macromolecules. This Review discusses the development of ordered, large-pore, functionalized mesoporous silicates and their application to the immobilization of proteins for biocatalysis.
Abstract
Mesoporous silicates (MPS) have an ordered pore structure with dimensions comparable to many biological molecules. They have been extensively explored as supports for proteins and enzymes in biocatalytic applications. Since their initial discovery, novel syntheses methods have led to precise control over pore size and structure, particle size, chemical composition, and stability, thus allowing the adsorption of a wide variety of biological macromolecules, such as heme proteins, lipases, antibody fragments, and proteases, into their structures. This Review discusses the application of ordered, large-pore, functionalized mesoporous silicates to immobilize proteins for biocatalysis.