We are grateful to the NIH (GM-58108) for support of this work and Johnson-Matthey for gifts of palladium. dppf=1,1′-bis(diphenylphosphino)ferrocene; Q-phos=1,2,3,4,5-pentaphenyl-1′-(di-tert-butylphosphino)ferrocene.
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Communication
Palladium-Catalyzed α-Arylation of Aldehydes with Bromo- and Chloroarenes Catalyzed by [{Pd(allyl)Cl}2] and dppf or Q-phos†
Article first published online: 7 FEB 2008
DOI: 10.1002/anie.200705357
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Issue
Angewandte Chemie International Edition
Volume 47, Issue 11, pages 2127–2130, February 28, 2008
Additional Information
How to Cite
Vo, Giang D. and Hartwig, John F. (2008), Palladium-Catalyzed α-Arylation of Aldehydes with Bromo- and Chloroarenes Catalyzed by [{Pd(allyl)Cl}2] and dppf or Q-phos. Angew. Chem. Int. Ed., 47: 2127–2130. doi: 10.1002/anie.200705357
- †
Publication History
- Issue published online: 22 FEB 2008
- Article first published online: 7 FEB 2008
- Manuscript Received: 21 NOV 2007
Funded by
- NIH. Grant Number: GM-58108
Keywords:
- aldehydes;
- arylation;
- cross-coupling;
- palladium
Pd source matters: A general method for palladium-catalyzed α-arylation of aldehydes (see scheme) was developed to couple linear and branched aldehydes with electron-poor and electron-rich bromo- and chloroarenes.