Communication

Biocompatible Carbon Nanotubes Generated by Functionalization with Glycodendrimers†

  1. Peng Wu3,‡,
  2. Xing Chen3,‡,
  3. Nancy Hu3,
  4. Un Chong Tam3,
  5. Ola Blixt4,
  6. Alex Zettl Prof.5,6,
  7. Carolyn R. Bertozzi Prof.1,2

Article first published online: 28 MAY 2008

DOI: 10.1002/anie.200705363

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 47, Issue 27, pages 5022–5025, June 23, 2008

Additional Information

How to Cite

Wu, P., Chen, X., Hu, N., Tam, U., Blixt, O., Zettl, A. and Bertozzi, Carolyn R. (2008), Biocompatible Carbon Nanotubes Generated by Functionalization with Glycodendrimers. Angew. Chem. Int. Ed., 47: 5022–5025. doi: 10.1002/anie.200705363

Author Information

  1. 1

    Departments of Chemistry and Molecular and Cell Biology and Howard Hughes Medical Institute, University of California

  2. 2

    The Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA 94720 (USA), Fax: (+1) 510-643-2628

  3. 3

    Department of Chemistry, University of California, Berkeley, CA 94720 (USA)

  4. 4

    Carbohydrate Synthesis and Protein Expression Core D, Consortium for Functional Glycomics, The Scripps Research Institute, La Jolla, CA 92037 (USA)

  5. 5

    Department of Physics, University of California

  6. 6

    Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720 (USA)

  1. ‡

    These authors contributed equally to the work.

  1. †

    This work was supported by the Director, Office of Energy Research, Office of Basic Energy Sciences, Division of Materials Sciences, of the U.S. Department of Energy under Contract No. DE-AC03-76SF00098, within the Interfacing Nanostructures Initiative and NIH (K99M080585-01). Portions of this work were performed at the Molecular Foundry, Lawrence Berkeley National Laboratory, which is supported by the Office of Science, Office of Basic Energy Sciences, of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231. 9 c was provided by Consortium for functional Glycomics.

Publication History

  1. Issue published online: 16 JUN 2008
  2. Article first published online: 28 MAY 2008
  3. Manuscript Received: 22 NOV 2007

Funded by

  • Director, Office of Energy Research, Office of Basic Energy Sciences, Division of Materials Sciences, of the U.S. Department of Energy. Grant Number: DE-AC03-76SF00098
  • NIH. Grant Number: K99M080585-01
  • Office of Science, Office of Basic Energy Sciences, of the U.S. Department of Energy. Grant Number: DE-AC02-05CH11231

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Keywords:

  • biomimetic synthesis;
  • carbon;
  • dendrimers;
  • glycoconjugates;
  • nanotubes
Thumbnail image of graphical abstract

Protective coatings: Glycodendrimers can function as homogeneous bioactive coatings that mitigate the cytotoxicity of single-walled carbon nanotubes (SWNTs). The bifunctional glycodendrimers (see picture) have peripheral carbohydrate units and a pyrene tail capable of binding SWNT surfaces through π–π interaction. Cells cultured with glycodendrimer-coated SWNTs proliferate at the same rate as untreated cells.

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