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Biocompatible Carbon Nanotubes Generated by Functionalization with Glycodendrimers

Authors


  • This work was supported by the Director, Office of Energy Research, Office of Basic Energy Sciences, Division of Materials Sciences, of the U.S. Department of Energy under Contract No. DE-AC03-76SF00098, within the Interfacing Nanostructures Initiative and NIH (K99M080585-01). Portions of this work were performed at the Molecular Foundry, Lawrence Berkeley National Laboratory, which is supported by the Office of Science, Office of Basic Energy Sciences, of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231. 9 c was provided by Consortium for functional Glycomics.

Abstract

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Protective coatings: Glycodendrimers can function as homogeneous bioactive coatings that mitigate the cytotoxicity of single-walled carbon nanotubes (SWNTs). The bifunctional glycodendrimers (see picture) have peripheral carbohydrate units and a pyrene tail capable of binding SWNT surfaces through π–π interaction. Cells cultured with glycodendrimer-coated SWNTs proliferate at the same rate as untreated cells.

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