Get access
Advertisement

Small-Molecule Inhibitors of Islet Amyloid Polypeptide Fibril Formation

Authors

  • Rajesh Mishra Dr.,

    1. Faculty of Chemistry, Physical Chemistry I—Biophysical Chemistry, Technical University Dortmund, Otto-Hahn-Strasse 6, 44227 Dortmund, Germany, Fax. (+49) 231-755-3901
    Search for more papers by this author
  • Bruno Bulic Dr.,

    1. Max-Planck-Institute for Molecular Physiology, Department of Chemical Biology, and Center for Applied Chemical Genomics, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany
    Search for more papers by this author
  • Daniel Sellin,

    1. Faculty of Chemistry, Physical Chemistry I—Biophysical Chemistry, Technical University Dortmund, Otto-Hahn-Strasse 6, 44227 Dortmund, Germany, Fax. (+49) 231-755-3901
    Search for more papers by this author
  • Suman Jha,

    1. Faculty of Chemistry, Physical Chemistry I—Biophysical Chemistry, Technical University Dortmund, Otto-Hahn-Strasse 6, 44227 Dortmund, Germany, Fax. (+49) 231-755-3901
    Search for more papers by this author
  • Herbert Waldmann Prof. Dr.,

    1. Max-Planck-Institute for Molecular Physiology, Department of Chemical Biology, and Center for Applied Chemical Genomics, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany
    Search for more papers by this author
  • Roland Winter Prof. Dr.

    1. Faculty of Chemistry, Physical Chemistry I—Biophysical Chemistry, Technical University Dortmund, Otto-Hahn-Strasse 6, 44227 Dortmund, Germany, Fax. (+49) 231-755-3901
    Search for more papers by this author

  • Financial support from the DFG, the Fonds der Chemischen Industrie, the country NRW and the EU (Europäischer Fonds für regionale Entwicklung) is gratefully acknowledged.

Abstract

original image

Small and effective: The pathological aggregation of amylin (IAPP), which leads to type II diabetes mellitus, is effectively inhibited by small-molecule rhodanine-based inhibitors at nanomolar concentrations. The prevention of aggregation by treatment with the inhibitor is demonstrated by AFM (see image).

Get access to the full text of this article

Ancillary