Communication

Rabe Rest in Peace: Confirmation of the Rabe–Kindler Conversion of d-Quinotoxine Into Quinine: Experimental Affirmation of the Woodward–Doering Formal Total Synthesis of Quinine†

  1. Aaron C. Smith Dr.1,
  2. Robert M. Williams Prof.1,2

Article first published online: 31 JAN 2008

DOI: 10.1002/anie.200705421

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 47, Issue 9, pages 1736–1740, February 15, 2008

Additional Information

How to Cite

Smith, Aaron C. and Williams, Robert M. (2008), Rabe Rest in Peace: Confirmation of the Rabe–Kindler Conversion of d-Quinotoxine Into Quinine: Experimental Affirmation of the Woodward–Doering Formal Total Synthesis of Quinine. Angew. Chem. Int. Ed., 47: 1736–1740. doi: 10.1002/anie.200705421

Author Information

  1. 1

    Department of Chemistry, Colorado State University, Fort Collins, CO 80523, USA, Fax: (+1) 970-491-3944

  2. 2

    University of Colorado Cancer Center, Aurora, CO 80045, USA

  1. †

    We are grateful to the National Institutes of Health for financial support (GM068011). Mass spectra were obtained on instruments supported by the NIH Shared Instrument Grant GM49631. We are particularly grateful to Prof. William von Eggers Doering of Harvard University for insightful and provocative discussions. We are indebted to Dr. Jeffrey I. Seeman for many thoughtful discussions and encouragement. We thank our co-workers, Dr. Thomas J. Greshock and Brandon English, for independently checking and repeating our best determined experimental conditions using the Rabe–Kindler conversion of d-quinotoxine into quinine procedure.

Publication History

  1. Issue published online: 11 FEB 2008
  2. Article first published online: 31 JAN 2008
  3. Manuscript Received: 26 NOV 2007

Funded by

  • National Institutes of Health. Grant Number: GM068011

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