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Keywords:

  • azides;
  • carbohydrates;
  • click chemistry;
  • glycoconjugates
Thumbnail image of graphical abstract

CuI-free click: 4-Dibenzocyclooctynol reacts, in the absence of a CuI catalyst, exceptionally fast with azido-containing saccharides and amino acids to give stable triazoles. A biotin-modified derivative is ideally suited for visualizing and tracking glycoconjugates of living cells that are metabolically labeled with azido-containing monosaccharides (see image).