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How Do Copper Enzymes Hydroxylate Aliphatic Substrates? Recent Insights from the Chemistry of Model Systems


  • The authors thank T. Schweikardt (Mainz) for Figure 1, which was made using the program YASARA.


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Copper at work: The aliphatic ligand hydroxylation by a copper–oxygen center has been observed for the first time on a model system of the enzyme PHM (peptidylglycine-α-hydroxylating monooxygenase). This result is put in the context of the enzymatic mechanism, which presumably involves a high-valent copper oxo unit (violet-red) that hydroxylates the substrate (cyan).

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