Protein-Cross-Linked Polymeric Materials through Site-Selective Bioconjugation


  • We gratefully acknowledge the Biomolecular Materials Program at LBNL and the UCB Chemical Biology Graduate Program for generous financial support. We also thank Prof. Jean M. Fréchet and Prof. Carolyn R. Bertozzi for the use of instrumentation and equipment.


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Creating a greener future: A strategy for creating hybrid materials of polymers and proteins relies on orthogonal reactions to activate the N and C termini of a protein concurrently. The protein is then used to cross-link polymer chains and create a hydrogel (see picture). A model hybrid hydrogel containing enhanced green fluorescent protein is both biodegradable and responsive to changes in pH and temperature.