Production of the Antifungal Isochromanone Ajudazols A and B in Chondromyces crocatus Cm c5: Biosynthetic Machinery and Cytochrome P450 Modifications

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Errata

This article is corrected by:

  1. Errata: Production of the Antifungal Isochromanone Ajudazols A and B in Chondromyces crocatus Cm c5: Biosynthetic Machinery and Cytochrome P450 Modifications Volume 48, Issue 52, 9773, Article first published online: 15 December 2009

  • We thank Dr. Josef Zapp from the Department of Pharmaceutical Biology for recording NMR spectra. This work was supported by the Deutsche Forschungsgemeinschaft (DFG).

Abstract

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Unusual biochemistry: The pathway to the antifungal ajudazols (ajudazol A is shown) has been deduced by cloning and sequencing of the gene cluster in the myxobacterium Chondromyces crocatus, coupled with insertional mutagenesis. Ajudazol biosynthesis incorporates several unusual features, including the first P450-catalyzed dehydrogenation identified in bacterial metabolism.

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