Influence of Amino Acid Side Chains on Long-Distance Electron Transfer in Peptides: Electron Hopping via “Stepping Stones”


  • This work was supported by the Swiss National Science Foundation. C.J. thanks the Leopoldina for a grant.


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It works both ways: The mechanism of electron transfer through peptides depends upon the side chain X located between the electron donor and the electron acceptor. Electron transfer occurs either by a slow single-step superexchange or by a two-step hopping process that is 20–30-times faster (see scheme). All intermediates in the hopping process could be observed simultaneously.