A Heterobimetallic Pd/La/Schiff Base Complex for anti-Selective Catalytic Asymmetric Nitroaldol Reactions and Applications to Short Syntheses of β-Adrenoceptor Agonists


  • This work was partially supported by a Grant-in-Aid for Specially Promoted Research from MEXT, and a Grant-in-Aid for Encouragements for Young Scientists (B) (Y.S.), from JSPS, and Mitsubishi Chemical Corporation Fund (S.M.), and Toray Co Ltd.


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Two metals in a pod: The combination of Pd and La with a dinucleating Schiff base was developed for anti selectivity in the catalytic asymmetric nitroaldol reaction (see scheme). Short syntheses of β-adrenoceptor agonists by using the heterobimetallic catalyst are presented.