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Keywords:

  • arylation;
  • cross-coupling;
  • heterogeneous catalysis;
  • iron;
  • thiols
Thumbnail image of graphical abstract

Strike while the iron is hot: An efficient iron-catalyzed protocol for the S-arylation of aromatic and heteroaromatic thiol derivatives has been developed, which involves an inexpensive catalyst system formed by combining FeCl3 and N,N′-dimethylethylenediamine at 135 °C. This method avoids the use of expensive and/or air-sensitive ligands and provides in most cases the desired sulfide in high yields.