We are grateful to the Fonds der Chemischen Industrie for financial support. A.C. thanks the Basque Government for support by “Programa de Perfeccionamiento de Doctores en el extranjero del Departamento de Educación, Universidades e Investigación”, and M.C. thanks the Spanish Ministry of Education and Sciences (MEC) for a postdoctoral fellowship.
Iron-Catalyzed S-Arylation of Thiols with Aryl Iodides†
Article first published online: 3 MAR 2008
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 47, Issue 15, pages 2880–2883, March 31, 2008
How to Cite
Correa, A., Carril, M. and Bolm, C. (2008), Iron-Catalyzed S-Arylation of Thiols with Aryl Iodides. Angew. Chem. Int. Ed., 47: 2880–2883. doi: 10.1002/anie.200705668
- Issue published online: 20 MAR 2008
- Article first published online: 3 MAR 2008
- Manuscript Received: 11 DEC 2007
- Fonds der Chemischen Industrie
- Basque Government
- heterogeneous catalysis;
Strike while the iron is hot: An efficient iron-catalyzed protocol for the S-arylation of aromatic and heteroaromatic thiol derivatives has been developed, which involves an inexpensive catalyst system formed by combining FeCl3 and N,N′-dimethylethylenediamine at 135 °C. This method avoids the use of expensive and/or air-sensitive ligands and provides in most cases the desired sulfide in high yields.