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Keywords:

  • aldol reaction;
  • asymmetric catalysis;
  • enantioselectivity;
  • hydroxylation;
  • regioselectivity
Thumbnail image of graphical abstract

New nucleophiles for the O-nitroso aldol reaction in the form of readily prepared disilanyl enol ethers make this transformation more practical and more versatile. A silver catalyst with a chiral biaryl phosphite ligand promotes the title reaction with high enantio- and regioselectivity (see scheme). R1,R2 = H, Ar; TMS = trimethylsilyl.