Both authors contributed equally to this paper.
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Communication
Synthesis of 1,9-Dideoxy-pre-axinellamine†
Article first published online: 20 MAR 2008
DOI: 10.1002/anie.200705913
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Yamaguchi, J., Seiple, Ian B., Young, Ian S., O'Malley, Daniel P., Maue, M. and Baran, Phil S. (2008), Synthesis of 1,9-Dideoxy-pre-axinellamine. Angew. Chem. Int. Ed., 47: 3578–3580. doi: 10.1002/anie.200705913
- †
We thank Dr. Arnold Rheingold (UCSD) for X-ray crystallographic assistance. Financial support for this work was provided by the NIH/NIGMS (GM-073949), Bristol–Myers Squibb, Merck, the Japan Society for the Promotion of Science (JSPS) for a postdoctoral fellowship to J.Y., the Natural Sciences and Engineering Research Council of Canada (NSERC) for a postdoctoral fellowship to I.S.Y., the U.S. Department of Defense and the Hertz Foundation for a predoctoral fellowships to D.P.O, and the German Academic Exchange Service (DAAD) for a postdoctoral fellowship to M.M.
Publication History
- Issue published online: 21 APR 2008
- Article first published online: 20 MAR 2008
- Manuscript Received: 22 DEC 2007
Funded by
- NIH/NIGMS. Grant Number: GM-073949
- Bristol–Myers Squibb
- Merck
- Japan Society for the Promotion of Science
- Natural Sciences and Engineering Research Council of Canada
- U.S. Department of Defense
- Hertz Foundation
- German Academic Exchange Service
Keywords:
- alkaloids;
- axinellamine;
- cascade reactions;
- palau'amine;
- total synthesis
Within reach: A 19-step route to 1,9-dideoxy-pre-axinellamine has been designed and executed. This key compound represents a hypothetical precursor to an entire family of alkaloid natural products.