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Keywords:

  • cytochrome P450;
  • endoperoxides;
  • enzyme models;
  • heme;
  • ligand effects
Thumbnail image of graphical abstract

A coordinated effort: The isomerization mechanism of prostaglandin H2 (PGH2), which is catalytically isomerized to prostacyclin or thromboxane A2 by cytochrome P450s, was investigated using a heme-thiolate complex and an endoperoxide. Isomerization of endoperoxides proceeded very rapidly with this complex, whereas imidazole- or chloride-ligated heme had slight or no catalytic activity (see scheme).