This work was supported by the Carolina Center for Cancer Nanotechnology Excellence, The National Cancer Institute, and the Burroughs Wellcome Foundation (Interface Career Award).
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Communication
An Electroactive Catalytic Dynamic Substrate that Immobilizes and Releases Patterned Ligands, Proteins, and Cells†
Article first published online: 20 JUN 2008
DOI: 10.1002/anie.200800166
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Chan, Eugene W. L., Park, S. and Yousaf, Muhammad N. (2008), An Electroactive Catalytic Dynamic Substrate that Immobilizes and Releases Patterned Ligands, Proteins, and Cells. Angew. Chem. Int. Ed., 47: 6267–6271. doi: 10.1002/anie.200800166
- †
Publication History
- Issue published online: 29 JUL 2008
- Article first published online: 20 JUN 2008
- Manuscript Revised: 16 APR 2008
- Manuscript Received: 12 JAN 2008
Funded by
- Carolina Center for
- The National Cancer Institute
- Burroughs Wellcome Foundation
Keywords:
- cell adhesion;
- electrochemistry;
- heterogeneous catalysis;
- monolayers;
- redox chemistry
Dynamic release: A quinone-terminated self-assembled monolayer captures and releases ligands and cells in situ through a pH-dependent electrochemical potential. The surface is catalytic for multiple rounds of immobilization/release. When combined with a photochemical approach, peptide ligands that mediate cell attachment are captured and released on defined gradient patterns (see picture).