An Electroactive Catalytic Dynamic Substrate that Immobilizes and Releases Patterned Ligands, Proteins, and Cells


  • This work was supported by the Carolina Center for Cancer Nanotechnology Excellence, The National Cancer Institute, and the Burroughs Wellcome Foundation (Interface Career Award).


original image

Dynamic release: A quinone-terminated self-assembled monolayer captures and releases ligands and cells in situ through a pH-dependent electrochemical potential. The surface is catalytic for multiple rounds of immobilization/release. When combined with a photochemical approach, peptide ligands that mediate cell attachment are captured and released on defined gradient patterns (see picture).